| Name | Vitamin K3 | ||
| PubChem CID | 4055 | ||
| Molecular Weight | 172.18g/mol | ||
| Synonyms |
2-Methyl-1,4-naphthalenedione, 2-Methyl-1,4-naphthoquinone, 2-Methylnaphthoquinone, Bisulfite, Menadione, Bisulfite, Menadione Sodium, Menadione, Menadione bisulfite, Menadione sodium bisulfite, Menadione sodium bisulfite, trihydrate, Sodium Bisulfite, Menadione, Vicasol, Vikasol, Vitamin K 3, Vitamin K3, Vitamin K3 sodium bisulfite |
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| Formula | C₁₁H₈O₂ | ||
| SMILES | CC1=CC(=O)C2=CC=CC=C2C1=O | ||
| InChI | 1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3 | ||
| InChIKey | MJVAVZPDRWSRRC-UHFFFAOYSA-N | ||
| CAS Number | 58-27-5 | ||
| ChEMBL ID | CHEMBL590 | ||
| ChEBI ID | CHEBI:28869 | ||
| Drug Bank ID | DB00170 | ||
| KEGG ID | C05377 | ||
| Toxicity | Organism | Test Type | Route(Dose) |
| rat | LD50 | intraperitoneal(165 mg/kg) | |
| mouse | LD50 | intraperitoneal(254 mg/kg) | |
| rat | LD50 | oral(322 mg/kg) | |
| Structure | 
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2D
MOL
3D
MOL
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| Chineses Pinyin | MuXu | ||
| Use Part | Root | ||
| Habitat | JiangXi, AnHui, JiangSu, ZheJiang, ShangHai | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Fabales
-->Family: Fabaceae
-->Genus: Medicago
-->Species: Medicago sativa
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| Pair Name | Vitamin K3, Auranofin | |||
| Partner Name | Auranofin | |||
| Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
| Biological Phenomena | Induction-->ROS accumulation | |||
| Gene Regulation | Up-regulation | Expression | TXNRD1 | hsa7296 |
| In Vitro Model | T98G | Glioblastoma | Homo sapiens (Human) | CVCL_0556 |
| U-87MG ATCC | Glioblastoma | Homo sapiens (Human) | CVCL_0022 | |
| LN-229 | Glioblastoma | Homo sapiens (Human) | CVCL_0393 | |
| Result | Our results identify TrxR1 as an attractive drug target and highlights AF as an off-patent drug candidate in GBM therapy. | |||
| Pair Name | Vitamin K3, Imatinib | |||
| Partner Name | Imatinib | |||
| Disease Info | [ICD-11: 2B33.2] | Chronic myeloid leukemia | Investigative | |
| Gene Regulation | Down-regulation | Expression | ABCB1 | hsa5243 |
| In Vitro Model | K-562 | Blast phase chronic myelogenous leukemia | Homo sapiens (Human) | CVCL_0004 |
| Result | The results demonstrate that menadione and imatinib combination therapy may be a promising approach to refractory CML. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Menadione Potentiates Auranofin-Induced Glioblastoma Cell Death. Int J Mol Sci. 2022 Dec 11;23(24):15712. doi: 10.3390/ijms232415712. | Click |
| 2 | The potentiation of menadione on imatinib by downregulation of ABCB1 expression. Clin Exp Pharmacol Physiol. 2020 Jun;47(6):997-1004. doi: 10.1111/1440-1681.13293. | Click |
